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Sermorelin
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⚠️ Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is Sermorelin?

Sermorelin is a synthetic peptide analogue of growth hormone–releasing hormone (GHRH 1–29). It stimulates the anterior pituitary to release endogenous growth hormone, thereby supporting IGF-1 production and downstream anabolic and metabolic effects. Sermorelin has been studied for growth hormone deficiency, age-related hormone decline, and metabolic health, offering a more physiological alternative to exogenous GH administration.

Key Research
  • Growth hormone release & endocrine regulation
  • IGF-1 stimulation & anabolic pathways
  • Muscle growth & recovery
  • Bone health & density support
  • Fat metabolism & body composition
  • Sleep quality & circadian rhythm
  • Anti-aging & longevity
  • Cognitive function & brain health
  • Cardiovascular & metabolic health
  • Stress resilience & systemic protection
Specifications
PropertyDetails
CAS Number86168-78-7
Chemical NameSermorelin (GHRH 1–29 amide)
PubChem CID 16132413
Molecular FormulaC149H246N44O42S
Molecular Weight ≈ 3357.9 g/mol
Physical AppearanceWhite to off-white lyophilized powder
FormSynthetic polypeptide (GHRH 1–29 analogue)
Container3 mL glass vial (2 mg net content)
Purity≥99% verified by HPLC & MS (batch COA via on-vial QR)
SolubilitySoluble in sterile water or compatible buffer; gently invert until fully dissolved; filter-sterilize if necessary
Intended Use Laboratory research only (RUO). Not for human or animal use.
Molecular Structure
Sermorelin molecular structure
FAQ

How much is in each vial?

Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.

Does it come with instructions?

USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.

What other supplies are needed?

Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.

How long does a vial last?

Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.

Is Sermorelin identical to natural GHRH?

No. Sermorelin is a synthetic fragment corresponding to the first 29 amino acids of GHRH, which are sufficient for biological activity.

Which in-vitro or experimental assays is Sermorelin commonly used in?

Common RUO applications include pituitary GH release assays, endocrine signaling studies, anabolic/metabolic models, and age-related hormone research.

What is its stability?

Lyophilized powder is stable at –20 °C; reconstituted solutions should be stored at 2–8 °C and used promptly.
References
  1. Bowers, C. Y., et al. “Growth Hormone Releasing Hormone (1–29)-NH2: Potent In Vivo and In Vitro Stimulation of GH Release.” Endocrinology, vol. 114, no. 5, 1984, pp. 1537–1545.  [Link]
  2. Kopchick, J. J., and A. Barkan. “Sermorelin and Other GHRH Analogs in Research.” Growth Hormone & IGF Research, vol. 21, no. 3, 2011, pp. 123–130. [Link]
  3. Walker, R. F., et al. “Pharmacokinetics and Pharmacodynamics of Sermorelin: A Synthetic GHRH (1–29) Amide.” Journal of Clinical Endocrinology & Metabolism, vol. 66, no. 2, 1988, pp. 395–400 [Link]
  4. Walker, R. F., et al. “Clinical Endocrine Evaluation of Sermorelin in Research Models of Growth Hormone Regulation.” Metabolism, vol. 39, no. 6, 1990, pp. 681–688. [Link]
  5. Wehrenberg, W. B., et al. “Mechanism of Action of GHRH and Sermorelin in Pituitary Cells.” Endocrine Reviews, vol. 11, no. 2, 1990, pp. 177–198. [Link]
Sermorelin
Sermorelin
2mg
$39.00
One-time

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Quality, Storage & Handling

Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purityquantity, and endotoxin.

  • Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
  • After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
  • Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.

Shipping

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.

Compliance & Research Use Only Disclaimer

For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.