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Semax
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⚠️ Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is Semax?

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH 4–10) with an added Pro-Gly-Pro sequence for stability. Developed in Russia, it is classified as a nootropic and neuroprotective peptide, with research showing benefits in regulating brain-derived neurotrophic factor (BDNF), protecting against ischemic damage, and supporting cognitive and stress resilience.

Key Research
  • Neuroprotection & brain health
  • Cognitive function & memory support
  • BDNF regulation & synaptic plasticity
  • Stress resilience & emotional balance
  • Ischemia & stroke recovery
  • Inflammation reduction & immune balance
  • Anti-aging & neurodegenerative support
  • Visual system & optic nerve protection
  • Pain modulation & recovery
  • Cellular repair & longevity pathways
Specifications
PropertyDetails
CAS NumberMay vary by salt form; see COA for identifiers
Chemical NameL-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
PubChem CID Linear heptapeptide with the sequence MEHFPGP. For lot-specific identifiers (salt form, exact formula/MW) and a structural rendering, scan the on-vial QR to access the COA.
Molecular FormulaSequence-dependent; reported on COA
Molecular Weight Sequence-dependent; reported on COA
Physical AppearanceWhite to off-white lyophilized powder
FormSynthetic heptapeptide
Container3 mL glass vial (5 mg net content)
Purity≥99% verified by HPLC & MS (batch COA via on-vial QR)
SolubilityReadily soluble in sterile water or neutral aqueous buffers; prepare fresh. If required by SOP, 0.22 µm filter after reconstitution.
Intended UseLaboratory research only (RUO). Not for human or animal use.
FAQ

How much is in each vial?

Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.

Does it come with instructions?

USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.

What other supplies are needed?

Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.

How long does a vial last?

Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.

Is this for human or veterinary use?

No. This product is sold strictly as RUO and must not be used in humans or animals.

What’s the exact salt form?

Most lots are provided as the acetate salt. Refer to the lot-matched COA/label for confirmed counter-ion and identifiers.

Which in-vitro assays is Semax commonly used in?

Typical RUO applications include neuropeptide pathway reporters, stress-response transcriptomics, peptidase-stability/uptake studies, and HPLC/LC–MS method development.
References
  1. Ashmarin, I. P., et al. “Semax, an analog of ACTH(4–10), regulates behavior and the central nervous system.” Neuroscience and Behavioral Physiology 22(1), 1992, 94–99.  [Link]
  2. Andreeva, L. A., et al. “The nootropic and anxiolytic effects of Semax.” Behavioral and Brain Functions 4, 2008, 25. [Link]
  3. Inozemtseva, L. S., et al. “Semax modulates the expression of genes related to brain-derived neurotrophic factor (BDNF) signaling in the rat hippocampus.” Molecular Neurobiology 55(5), 2018, 3925–3934. [Link]
  4. Myasoedov, N. F., et al. “Peptide Semax in prevention and treatment of ischemic brain injury: preclinical and clinical studies.” Brain Research Reviews 65(1), 2010, 41–55.  [Link]
  5. Dolotov, O. V., et al. “Semax, an analog of ACTH(4–10), regulates memory processes and induces expression of BDNF and TrkB in rat brain.” Neurochemical Journal 6(1), 2012, 49–57.  [Link]
Semax
Semax
5mg
$39.00
One-time

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Quality, Storage & Handling

Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purityquantity, and endotoxin.

  • Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
  • After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
  • Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.

Shipping

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.

Compliance & Research Use Only Disclaimer

For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.