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PT-141
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⚠️ Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is PT-141?

PT-141 (Bremelanotide) is a synthetic peptide and melanocortin receptor agonist originally derived from the α-MSH (alpha-melanocyte-stimulating hormone) peptide family. Unlike PDE5 inhibitors that act on vascular systems, PT-141 works centrally on the nervous system, activating melanocortin-4 receptors (MC4R) to enhance sexual desire and arousal. It is FDA-approved for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women and is also studied for sexual dysfunction in men.

Key Research
  • Sexual health & arousal
  • Treatment of hypoactive sexual desire disorder (HSDD)
  • Erectile function & male sexual health
  • Central melanocortin receptor signaling
  • Brain health & neuroendocrine regulation
  • Stress resilience & mood balance
  • Anti-aging & vitality support
  • Cardiovascular & endothelial function
  • Energy balance & body composition
  • Hormonal modulation & systemic health
Specifications
PropertyDetails
CAS Number189691-06-3
Chemical NameBremelanotide (Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH); PT-141
PubChem CID 9941379
Molecular FormulaC50H68N14O10
Molecular Weight ≈ 1025.18 g/mol
Physical AppearanceWhite to off-white lyophilized cake/powder
FormLyophilized powder (freeze-dried)
ContainerSterile Type I glass vial; 10 mg net content; QR batch ID
Purity ≥99% verified by HPLC & MS (batch COA via on-vial QR)
SolubilitySoluble in sterile water or compatible aqueous buffer; optimize pH/ionic strength per assay; filter (0.22 µm) if sterility is required by your protocol
Intended UseLaboratory research only (RUO). Not for human or animal use.
Molecular Structure
PT-141 molecular structure
FAQ

How much is in each vial?

Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.

Does it come with instructions?

USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.

What other supplies are needed?

Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.

How long does a vial last?

Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.

Is this intended for human or veterinary use?

No. This product is sold strictly as RUO and must not be used in humans or animals.

How should I reconstitute it?

Use sterile water or a compatible buffer; gently invert until fully dissolved. If your protocol requires sterility, pass through a 0.22 µm filter and aliquot to avoid repeat freeze–thaw.

Which in-vitro assays is PT-141 commonly used in?

Typical RUO uses include melanocortin receptor cAMP assays, β-arrestin/internalization workflows, radioligand binding, and LC–MS/MS method development.
References
  1. PubChem Compound Summary: Bremelanotide (PT-141).  [Link]
  2. The Merck Index Online — Bremelanotide monograph (formula & MW). [Link]
  3. DrugBank. “Bremelanotide: Uses, Interactions, Mechanism of Action.”  [Link]
  4. Liu, Z., et al. “MC4R biased signalling and the conformational basis for ligand function.” Cell Mol Life Sci, 2022.  [Link]
  5. (Sequence/topology reference) PT-141 monograph: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH; C50H68N14O10.  [Link]
PT-141
PT-141
10mg
$55.00
One-time

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Quality, Storage & Handling

Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purityquantity, and endotoxin.

  • Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
  • After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
  • Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.

Shipping

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.

Compliance & Research Use Only Disclaimer

For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.