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Melanotan II
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⚠️ Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is Melanotan II?

Melanotan II (MT-II) is a synthetic analog of the endogenous peptide α-melanocyte-stimulating hormone (α-MSH) that binds to melanocortin receptors (MC-1R through MC-5R). It is studied for its ability to stimulate melanin production, enhance UV protection, and influence libido, appetite, and energy regulation through central melanocortin pathways. Research explores Melanotan II’s roles in skin pigmentation, metabolic balance, and neuroendocrine signaling, making it a multifunctional molecule of interest in dermatology, sexual health, and metabolism.

Key Research
  • Skin pigmentation & melanin synthesis
  • UV protection & photodamage prevention
  • Sexual health & libido modulation
  • Appetite regulation & energy balance
  • Fat metabolism & body composition
  • Hormonal signaling & neuroendocrine function
  • Mood, motivation & dopaminergic activity
  • Cardiovascular & endothelial health
  • Stress resilience & oxidative protection
  • Anti-inflammatory & immune balance
Specifications
PropertyDetails
CAS Number121062-08-6
Chemical NameAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (Melanotan II; MT-2
PubChem CID 92432
Molecular FormulaC50H69N15O9
Molecular Weight≈ 1024.18 g/mol
Physical AppearanceWhite to off-white lyophilized powder
FormSynthetic cyclic heptapeptide analog (lyophilized acetate salt)
Container3 mL glass vial (10 mg net content)
Purity ≥99% verified by HPLC & MS (lot COA via QR)
SolubilitySoluble in sterile water or compatible aqueous buffer; gentle agitation/brief sonication may aid dissolution. Optimize pH/ionic strength for your assay; filter-sterilize if required.
Intended UseLaboratory research only (RUO). Not for human or animal use.
Molecular Structure
Melanotan II molecular structure
FAQ

How much is in each vial?

Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.

Does it come with instructions?

USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.

What other supplies are needed?

Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.

How long does a vial last?

Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.

Is this intended for human or veterinary use?

No. This product is sold strictly as RUO, not for human or animal use.

What purity do you provide?

Each 10 mg vial is ≥99% by HPLC with MS identity confirmation; third-party testing is performed on every lot (see the COA via QR).

How should I reconstitute it?

Use sterile water or a compatible aqueous buffer; gently invert until fully dissolved. If your protocol requires sterility, pass through a 0.22 µm filter and aliquot to avoid repeat freeze–thaw.

Which in-vitro assays is MTII commonly used in?

Typical RUO applications include melanocortin receptor cAMP assays, β-arrestin/internalization workflows, radioligand binding, and LC–MS/MS method development.
References
  1. Hadley, M. E., et al. Structure–activity relationships of synthetic melanotropins: stimulation of melanogenesis and sexual behavior. Annals of the New York Academy of Sciences 994, 2003, 372–385. [Link]
  2. Wessells, H., et al. Effect of Melanotan II on penile erection and sexual desire in men with erectile dysfunction. Urology 60(4), 2002, 497–502 [Link]
  3. Dorr, R. T., et al. Cutaneous and systemic effects of the cyclic melanotropin analog Melanotan II in humans. Annals of the New York Academy of Sciences 994, 2003, 496–504.  [Link]
Melanotan II
Melanotan II
10mg
$30.00
One-time

Why Buy from USA Peptides Direct

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Quality, Storage & Handling

Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purityquantity, and endotoxin.

  • Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
  • After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
  • Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.

Shipping

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.

Compliance & Research Use Only Disclaimer

For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.