Adipotide
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$69.95
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⚠️ Research Use Only
These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
What is Adipotide?
Key Research
Specifications
| Property | Details |
|---|---|
| CAS Number | 859216-15-2 |
| Chemical Name | Adipotide; Prohibitin-Targeting Peptide-1 (Prohibitin-TP01) |
| PubChem CID | 16143998 |
| Molecular Formula | CKGGRAKDC-GG-D(KLAKLAK)2 |
| Molecular Weight | ~2.5–2.6 kDa (varies by salt form) |
| Physical Appearance | White to off-white lyophilized powder |
| Form | Synthetic peptidomimetic (lyophilized acetate salt) |
| Container | 3 mL glass vial (5 mg net content) |
| Purity | ≥ 99% verified by HPLC & MS |
| Solubility | Soluble in sterile water or compatible aqueous buffer; gently invert until dissolved; filter-sterilize (0.22 µm) if your application requires sterility |
| Intended Use | Laboratory research only (RUO). Not for human or animal use. |
Molecular Structure
FAQ
How much is in each vial?
Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.
Does it come with instructions?
USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.
What other supplies are needed?
Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.
How long does a vial last?
Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.
Is Adipotide a natural peptide?
No. Adipotide is a synthetic peptidomimetic composed of a targeting domain (CKGGRAKDC) linked to a pro-apoptotic domain (KLAKLAKKLAKLAK). It was engineered to selectively bind to prohibitin receptors expressed in adipose tissue vasculature.
How should I reconstitute it?
Use sterile, room-temperature water for injection (WFI) or a neutral buffer. Gently invert to dissolve completely. Avoid vigorous shaking or repeated freeze–thaw cycles.
What concentration is recommended for in-vitro research?
Adipotide has been studied in concentrations ranging from 1–50 μM, depending on assay type and cell line. It is commonly used in research on adipocyte biology, angiogenesis, and metabolic regulation.
Which pathways are most relevant for Adipotide studies?
Primary research focuses on the prohibitin-mediated vascular apoptosis, AMPK activation, and lipid oxidation pathways in adipose and hepatic models.
References
- Kolonin, Mikhail G., et al. “Reversal of Obesity by Targeted Ablation of Adipose Tissue.” Nature Medicine, vol. 10, no. 6, 2004, pp. 625–632. [Link]
- Barnhart, Kimberly F., et al. “A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys.” Science Translational Medicine, vol. 3, no. 108, 2011, 108ra112. [Link]
- Salameh, Ahmad, et al. “Prohibitin/Annexin 2 Interaction Regulates Fatty Acid Transport in Adipose Tissue.” JCI Insight, vol. 1, no. 10, 2016, e86351 [Link]
- Ellerby, H. Michael, et al. “Anti-Cancer Activity of Targeted Pro-Apoptotic Peptides.” Nature Medicine, vol. 5, no. 9, 1999, pp. 1032–1038. [Link]
- Delgado, J. M., et al. “A Proapoptotic Peptide for the Treatment of Solid Tumors.” Cancer Research, vol. 61, no. 21, 2001, pp. 7709–7712. [Link]
Adipotide
5mg
$69.95
One-time
Why Buy from USA Peptides Direct
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Quality, Storage & Handling
Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purity, quantity, and endotoxin.
- Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
- After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
- Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.
Shipping
Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.
Compliance & Research Use Only Disclaimer
For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.