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TB-500
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⚠️ Research Use Only

These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.

What is TB-500?

TB-500 is the synthetic version of a naturally occurring peptide fragment of thymosin beta-4, a protein involved in cellular regeneration and tissue repair. It plays a role in actin binding, angiogenesis, wound healing, and anti-inflammatory responses. TB-500 has been widely studied in preclinical models for its potential to accelerate recovery, support muscle and tendon healing, and improve tissue remodeling.

Key Research
  • Tissue repair & regeneration
  • Angiogenesis & vascular health
  • Muscle healing & recovery
  • Tendon & ligament support
  • Anti-inflammatory & immune modulation
  • Wound healing & scar reduction
  • Cardiovascular protection & remodeling
  • Neuroprotection & brain health
  • Anti-aging & longevity support
  • Stress resilience & systemic balance
Specifications
PropertyDetails
CAS Number77591-33-4
Chemical NameThymosin β4 (timbetasin)
PubChem CID 16132341
Molecular FormulaC212H350N56O78S
Molecular Weight≈ 4,963.5 g/mol
Physical AppearanceWhite to off-white lyophilized powder
FormSynthetic peptide fragment (Thymosin beta-4 derivative)
Container3 mL glass vial (10 mg net content)
Purity≥99% verified by HPLC & MS (batch COA via on-vial QR)
SolubilitySoluble in sterile water or isotonic buffer; gentle inversion/brief sonication may aid dissolution. Filter-sterilize if required by your assay.
Intended UseLaboratory research only (RUO). Not for human or animal use.
Molecular Structure
TB-500 molecular structure
FAQ

How much is in each vial?

Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.

Does it come with instructions?

USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.

What other supplies are needed?

Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.

How long does a vial last?

Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.

Is this listing full-length Thymosin β4?

Yes, this TB-500 corresponds to full-length human Tβ4 (43 aa). Contact support if you need a specific fragment.

How should I reconstitute it?

Use sterile water or a compatible buffer; gently invert until dissolved. If your protocol requires sterility, 0.22 µm filter-sterilize and aliquot to avoid repeat freeze–thaw.

Which in-vitro assays is TB-500 commonly used in?

Typical RUO applications include actin polymerization/sequestration assays, cell-migration models, ECM remodeling panels, and LC–MS/MS identity/stability method development.
References
  1. Philp, D., et al. “Thymosin β4 promotes angiogenesis and wound healing.” Journal of Investigative Dermatology 113(3), 1999, 364–368.  [Link]
  2. Bock-Marquette, I., et al. “Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and cardiac repair.” Nature 432(7016), 2004, 466–472.  [Link]
  3. Goldstein, A. L., Hannappel, E., Kleinman, H. K. “Thymosin β4: actin-sequestering protein moonlights to repair injured tissues.” Trends in Molecular Medicine 11(9), 2005, 421–429.  [Link]
  4. Smart, N., et al. “Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization.” Nature 445(7124), 2007, 177–182. [Link]
  5. Crockford, D., Turjman, N., Allan, C., Angel, J. “Thymosin β4: structure, function, and biological properties supporting current and future clinical applications.” Annals of the New York Academy of Sciences 1194, 2010, 179–189 [Link]
TB-500
TB-500
5mg
$79.00
One-time

Why Buy from USA Peptides Direct

  • USA Made
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  • GMP-Standard lyophilization, documented & traceable
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Quality, Storage & Handling

Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purityquantity, and endotoxin.

  • Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
  • After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
  • Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.

Shipping

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.

Compliance & Research Use Only Disclaimer

For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.