MOTS-c
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$110.00
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⚠️ Research Use Only
These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
What is MOTS-c?
Key Research
Specifications
| Property | Details |
|---|---|
| CAS Number | 1627580-64-6 |
| Chemical Name | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MOTS-c) |
| PubChem CID | 146675088 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | ≈ 2174.6 g/mol |
| Physical Appearance | White to off-white lyophilized powder |
| Form | Mitochondria-derived hexadecapeptide (16 aa) |
| Container | 3 mL glass vial (10 mg net content) |
| Purity | ≥99% verified by HPLC & MS (batch COA via on-vial QR) |
| Solubility | Soluble in sterile water or compatible aqueous buffer; gentle agitation recommended. If required by protocol, 0.22 µm filter-sterilize. |
| Intended Use | Laboratory research only (RUO). Not for human or animal use. |
Molecular Structure
FAQ
How much is in each vial?
Each vial contains precisely the amount indicated on the label. For instance, a 10mg vial includes precisely 10mg of lyophilized peptide. Researchers may divide it into smaller fractions, such as four 2.5mg portions, while the total amount remains 10mg.
Does it come with instructions?
USA Peptides Direct products are designated for in vitro research. Prior to working with them, conduct thorough research. Our team will offer general assistance via text post-purchase.
What other supplies are needed?
Peptides come as lyophilized powder. They are not reconstituted, and any necessary bacteriostatic water or syringes must be obtained separately for research purposes.
How long does a vial last?
Peptides remain stable for up to 2 years in lyophilized powder form. After reconstitution, refrigerate and expect stability for about 2 months.
How should I reconstitute it?
Use sterile water or a compatible aqueous buffer; gently invert until fully dissolved. If your protocol requires sterility, pass through a 0.22 µm filter and aliquot.
Which in-vitro assays is MOTS-c commonly used in?
Typical RUO applications include AMPK signaling, stress-response profiling, mitochondrial bioenergetics (OCR/ECAR), kinase-interaction assays, and LC–MS/MS method validation.
References
- Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S. J., et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism 21(3), 2015, 443–454. [Link]
- Kim, K. H., Son, J. M., Benayoun, B. A., Lee, C. “The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress.” Cell Metabolism 28(3), 2018, 516–524.e7. [Link]
- Reznick, R. M., et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications 11, 2020, 4473. [Link]
- Lu, H., et al. “MOTS-c peptide prevents osteoporosis by promoting bone formation and inhibiting bone resorption.” Bone Research 9, 2021, 9. [Link]
- Zhang, Y., et al. “MOTS-c improves endothelial function and reduces vascular aging by activating AMPK signaling.” Frontiers in Cardiovascular Medicine 9, 2022, 886108. [Link]
MOTS-c
10mg
$110.00
One-time
Why Buy from USA Peptides Direct
- USA Made
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- GMP-Standard lyophilization, documented & traceable
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Quality, Storage & Handling
Each lot is confirmed by HPLC (purity) and MS (identity); QR on the vial links to the batch COA. Independent U.S. labs verify purity, quantity, and endotoxin.
- Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
- After reconstitution: Use neutral, oxygen-poor buffer when possible; aliquot and store at ≤−20 °C; avoid repeated freeze–thaw.
- Working solutions: Prepare fresh; minimize exposure to light/alkaline pH to reduce degradation.
Shipping
Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included.
Compliance & Research Use Only Disclaimer
For laboratory research only. All articles are product information provided on this website are for informational and educational purposes only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.